Anna Kabanova
Anna Kabanova is an immunologist interested in harnessing B/T cell biology for treatment of tumours and infectious diseases. In Siena she develops projects on mechanisms of tumour suppression and artificial cell therapies in B cell leukemia supported by the Italian Cancer Research Association, Italian Ministry of Research and European Innovation Council. Along with that, owing to experience in vaccinology and B cell response against pathogens, she collaborates with the Monoclonal Antibody Discovery lab (MAD Lab) research team at Fondazione TLS working in the identification and characterization of monoclonal antibody against pandrug-resistant bacteria.
Anna received her PhD degree from the University of Bologna and worked as a postdoctoral fellow with Prof. Antonio Lanzavecchia at the Institute for Research in Biomedicine in Bellinzona, Switzerland, and Prof. Cosima Baldari at the University of Siena.
Honors and Awards
2019-2024 Member and Vice chair, Young EHA committee, European Hematology Association
2018 Prize of the Foundation “Carlo Chianello for research in clinical and experimental oncology, University of Palermo, Italy
2015 AIRC TRIDEO award “Transforming Ideas in Oncological research”
Selected Publications
Roscioli, E., Zucconi, V., Bosch, S., …, Sala, C., Kabanova, A., Rappuoli, R. Anti-capsule human monoclonal antibodies protect against hypervirulent and pandrug-resistant Klebsiella pneumoniae. BioRXiv
Nardi, F., Pezzella, L., …, Gozzetti, A., Bocchia M., Kabanova, A. Assessing gene function in human B cells: CRISPR/Cas9-based gene editing and mRNA-based gene expression in healthy and tumor cells. Eur J Immunol. 52(8):1362-1365 (2022)
Zurli, V., Montecchi, T., … Acuto, O., Baldari, C.T., Kabanova, A. Phosphoproteomics of CD2 signaling reveals AMPK-dependent regulation of lytic granule polarization in cytotoxic T cells. Sci Signal. 13(631):eaaz1965 (2020)
Zurli, V., Wimmer, G., … Baldari, C.T., Kabanova, A. Ectopic ILT3 controls BCR- driven activation of Akt in B-cell chronic lymphocytic leukemia. Blood 130 (18):2006-2017 (2017)
Kabanova, A., … Bocchia, M., Baldari, C.T. Human cytotoxic T lymphocytes form dysfunctional immune synapses with B cells characterized by non-polarized lytic granule release. Cell Reports 15, 1-10 (2016)
Kabanova, A., Marcandalli, J., … Lanzavecchia, A., Perez, L. Platelet-derived growth factor-α receptor is the cellular receptor for human cytomegalovirus gHgLgO trimer. Nature Microbiology pii: 16082 (2016)
Kabanova, A., Perez, L., … Lanzavecchia, A. Antibody-driven design of a human cytomegalovirus gHgLpUL128L subunit vaccine that selectively elicits potent neutralizing antibodies. Proc Natl Acad Sci U S A. 16;111(50):17965-70 (2014)
